Review of Research Paper on Metastasis of Cancerous Tumors

Introduction Early diagnosis provides the best hope many have in beating cancer. Unfortunately, this is not the end of the fight for many cancer patients. Primary tumors may be successfully treated early, only to later discover they have metastasized to other areas of the body. The common medical definition of metastasis is: The spread of cancer from one part of the body to another. Tumors formed from cells that have spread are called â€Å"secondary tumors† and contain cells that are like those in the original (primary) tumor. This definition could be the reason why early treatment of a primary tumor is ineffective against metastatic tumor cells. As the definition suggests, the accepted model†¦show more content†¦Of these test were the PCR, CGH, LOH, and genomic loci probability evaluation test. From these experiments, a conclusion was then formed about whether cancer cells differentiated before metastasis. Listed below are the procedures in detail. These are the procedures/ techniques performed: *Tumor Cell Detection and Sample Preparation: -386 breast cancer patients had bone marrow aspirated. :Of patients with no signs of metastasis who had samples drawn: -44% drawn before surgery -39% in next month -17% 1month to 10 years after surgery of primary tumor -Bone marrow suspensions. -Staining, tumor cell isolation, comparative genomic hybridization -Micro dissection of primary tumor, tissue preparation -PCR and CGH of isolated DNA Samples were drawn to perform the PCR and CGH tests for isolated DNA: *Loss of Heterozygosity Analysis(LOH): -Analysis of primary PCR and micro dissected tumors and single cells -Addition of microsatellite markers and primers to DNA -Scanning of Polyacrylamide gels by FluorImager *BioInformatic Evaluation: -46 genomic loci features selected and ranked according to information status -defined the presence of clinically evident metastatic targets -built classifier that assigns each cell its probability of being isolated from M1 patients, based on clinical variables of the primary tumor and genomic loci of isolated tumor cell. :Genomic Loci were selected to identify and differentiate cells. ByShow MoreRelatedLung Cancer : The Highest Mortality Rate1688 Words   |  7 PagesAccording to a paper published by the Center for Diseases and Control, Lung Cancer has the highest mortality rate in the US than any other cancer type. In 2011, about 156,953 people died from the disease as about 207,000 cases of ailing lung cancer patients were diagnosed that year. This number is set to see an increase over the years if adequate care in research is not given .Song described Lung cancer, as Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC) with the former beingRead MoreThe Use Of Breath Testing On The Management Of Cancer Patients1635 Words   |  7 PagesWith the ceaseless quest in health research for improved outcomes in the management of cancer patients, novel approaches to screening, diagnosis, and treatment are highly sought after. In particular, effective and relatively low cost screening tests may play an invaluable role in reducing patient mortality resulting from diagnosis early in the disease process which is crucial for proactive measures and successful therapy. However, it is critical to remain mindful of the risk of harm related to falseRead MoreThe s Innate Immunity Of A Patient2180 Words   |  9 PagesTLR-9 plays a pivotal role in a host’s inborn and adaptive immunity. The latest research into boosting the innate immunity of a patient has caused the introduction of TLRs treatment to manage cancerous cells (Coussens Werb, 2013). The mice breast cell line seasoned for breast cancer was found to express TLR-9 at both the protein and the mRNA levels. It is evident that TLR-9 signaling and pathways directly inhibit tumor growth or improve immunotherapy in patients suffering from prostate cancer. TheRead MoreModule Quizzes Essay14245 Words   |  57 Pages Comparator will turn on the controlled Where should you go to find updates on the course? Announcements in Bioespresso Where should you go to access your readings and assignments? www.bioespresso.com Where do you submit your extra credit paper? Dr. Pozo’s office A student athlete presents Dr. Pozos with documentation that he had an school-sponsored athletic event and was unable to complete the module. Dr. Pozos opens the emodule for the student and the student forgets to take the emodule